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週次 |
日期 |
單元主題 |
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第1週 |
9/17 |
課程介紹、分組與評分標準 |
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第2週 |
9/24 |
Immunologic Specificity: the concepts and solutions
Chapters 6 & 7 in “A history of Immunology” by Arthur M. Silverstein, 2nd edition
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第3週 |
10/01 |
The adaptive immune system
1. The Divergence of Lymphocyte Development Pathways J Immunol 2006 176: 6369-6369
PA:The Functions of the Thymus System and the Bursa System in the Chicken. J. Exp. Med. 1966. 123: 75–102
2. The Beginnings of T-B Collaboration J Immunol 2004 173: 7-8
PA: Immunocompetence of Transferred Thymus-Marrow Cell Combinations. J. Immunol. 1966. 97:828-832
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第4週 |
10/08 |
The molecular basis view of antibody diversity
1. Wu and Kabat 1970: A Transforming View of Antibody Diversity
J Immunol 2008 180: 7055-7056
PA: An Analysis of the Sequences of the Variable Regions of Bence Jones Proteins and Myeloma Light Chains and their Implications for Antibody Complementarity. J. Exp. Med. 1970. 132: 211–250
2. The Birth of Molecular Immunology J Immunol 2004 173: 4259-4259
PA: Evidence for Somatic Rearrangement of Immunoglobulin Genes Coding for Variable and Constant Regions. Proc. Natl. Acad. Sci. USA. 1976. 73: 3628-3632
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第5週 |
10/15 |
B cell tolerance: clonal deletion and receptor editing
1. Nossal and Pike 1975: A Turning Point in the Effort to Define Self-Tolerance
Mechanisms J Immunol 2007 179: 5617-5618
PA: Evidence for the Clonal Abortion Theory of B-Lymphocyte Tolerance. J. Exp. Med. 1975. 141: 904–917
2. Receptor Editing as a Mechanism of B Cell Tolerance
J Immunol 2011 186: 1301-1302
PA: Receptor Editing in Self-reactive Bone Marrow B Cells. J. Exp. Med. 1993.
177: 1009–1020
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第6週 |
10/22 |
Nature Immunology Focus
The promise and challenge of high-throughput sequencing of the antibody repertoire
Nature Biotechnology 32, (2014)
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第7週 |
10/29 |
Requirements for T cell activation: antigen and MHC
1. T Cells Stop to Smell the (Antigenic) Roses J Immunol 2006 177: 1379-1380
PA: Antigen-Induced Selective Recruitment of Circulating Lymphocytes. Cell. Immunol. 1971. 2: 171–181
2. Shaping the T Cell Repertoire J Immunol 2005 175: 7067-7068
PA: The Major Histocompatibility Complex Determines Susceptibility to Cytotoxic T Cells Directed against Minor Histocompatibility Antigens. J. Exp. Med. 1975. 142: 1349–1364
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第8週 |
11/05 |
Shaping the T cell repertoire
1. Proving Negative Selection in the Thymus J Immunol 2005 174: 3841-3842
PA:T Cell Tolerance by Clonal Elimination in the Thymus Cell. 1987. 49: 273–280
2. Positive Selection in the Thymus: An Enigma Wrapped in a Mystery
J Immunol 2012 188: 2043-2045
PA: T Cell Receptor Antagonist Peptides Induce Positive Selection. Cell. 1994. 76: 17–27
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第9週 |
11/12 |
Antigen processing and presentation
1. Making Antigen Presentable J Immunol 2007 179: 3-4
PA: Identification of a Macrophage Antigen-Processing Event Required for
I-Region-Restricted Antigen Presentation to T Lymphocytes. J. Immunol. 1981. 127: 1869–1875
2. Characterizing MHC-Associated Peptides by Mass Spectrometry
J Immunol 2007 179: 2667-2668
PA: Characterization of Peptides Bound to the Class I MHC Molecule HLA-A2.1 by Mass Spectrometry. Science. 1992. 255: 1261–1263
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第10週 |
11/19 |
The birth of immune cell subsets: CD4/CD8, DC
1. The Birth of Functionally Distinct T Cell Subsets J Immunol 2006 176: 3859-3860
PA:Functional Subclasses of T Lymphocytes Bearing Different Ly Antigens. I. The
Generation of Functionally Distinct T-Cell Subclasses is a Differentiative Process Independent of Antigen. J. Exp. Med. 1975. 141: 1376–1389
2. The Birth of a Cell Type J Immunol 2007 178: 3-4
PA: Identification of a Novel Cell Type in Peripheral Lymphoid Organs of Mice. I.
Morphology, Quantitation, Tissue Distribution. J. Exp. Med. 1973. 137: 1142–1162
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第11週 |
11/26 |
Not just CD4/CD8 cell subsets: Th1/Th2, regulatory T cells
1. The World of Th1/Th2 Subsets: First Proof J Immunol 2005 175: 3-4
PA: Two Types of Murine Helper T Cell Clone. I. Definition According to Profiles of
Lymphokine Activities and Secreted Proteins. J. Immunol. 1986. 136: 2348–2357
2. The Resurrection of T Cell-Mediated Suppression J Immunol 2011 186: 3805-3807
PA: Immunologic Self-Tolerance Maintained by Activated T Cells Expressing IL-2 Receptor α-Chains(CD25). Breakdown of a Single Mechanism of Self-Tolerance Causes Various Autoimmune Diseases. J. Immunol. 1995. 155: 1151–1164
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第12週 |
12/03 |
Nature Immunology Focus
Beyond model antigens: high-dimensional methods for the analysis of antigen-specific T cells. Nature Biotechnology 32, (2014)
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第13週 |
12/10 |
準備週 (沒有報告) |
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第14週 |
12/17 |
Lymphocyte Costimulation
1. Turning the Tide of Lymphocyte Costimulation J Immunol 2009 182: 2557-2558
PA: T-Cell Antigen CD28 Mediates Adhesion with B Cells by Interacting with Activation Antigen B7/BB-1. Proc. Natl. Acad. Sci. USA. 1990. 87: 5031–5035
2. CTLA-4: Not All Costimulation Is Stimulatory J Immunol 2011 187: 3457-3458
PA: CD28 and CTLA-4 Have Opposing Effects on the Response of T Cells to Stimulation. J. Exp. Med. 1995. 182: 459–465
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第15週 |
12/24 |
Toll-mediated innate immunity
1. How Discovery of Toll-Mediated Innate Immunity in Drosophila Impacted Our Understanding of TLR Signaling (and Vice Versa) J Immunol 2012 188: 5207-5209
PA: The Dorsoventral Regulatory Gene Cassette spatzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults. Cell. 1996. 86: 973-983
2. MyD88: A Critical Adaptor Protein in Innate Immunity Signal Transduction J Immunol 2013 190: 3-4
PA: MyD88: An Adapter That Recruits IRAK to the IL-1 Receptor Complex. Immunity. 1997. 7: 837–847
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第16週 |
12/31 |
Special seminar |
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第17週 |
1/07 |
Mini in-house seminar |